chemistry controlled study nonhuman 263 metabolism 225 Article 202 unclassified drug 197 Animals 182 animal 182 priority journal 180 human 154 article 153 Humans 150 genetics 92 animal cell 82 drug effects 80 human cell 80 female 70 in vitro study 67 physiology 66 animal experiment 54 drug effect 52 male 52 mouse 52 Female 50 chemical structure 50 animal tissue 49 protein expression 49 Male 48 Mice 46 enzymology 44