controlled study metabolism signal transduction priority journal 133 nonhuman 132 Animals 128 animal 128 Signal Transduction 127 human 108 Humans 104 Article 102 genetics 98 article 97 animal cell 88 mouse 88 protein expression 78 human cell 74 physiology 73 Mice 72 unclassified drug 64 female 63 animal experiment 60 Female 57 drug effects 52 animal tissue 51 male 48 enzyme activation 47 gene expression regulation 47 phosphorylation 45 Phosphorylation 43