controlled study metabolism physiology nonhuman 287 Animals 257 animal 257 priority journal 211 Article 170 article 161 animal experiment 149 animal tissue 125 mouse 119 animal cell 116 male 114 human 109 Humans 105 female 105 unclassified drug 100 genetics 97 Male 96 Mice 91 drug effect 84 protein expression 81 Female 80 signal transduction 73 human cell 62 drug effects 61 cytology 57 gene expression 57 rat 55