ATP binding 2 Activation loops 2 Active site 2 Adenosine Triphosphate 2 Allosteric Regulation 2 Amino acids 2 Binding energy 2 Bound state 2 Catalyst activity 2 Catalytic activity 2 Conformational change 2 Correlated dynamics 2 Docking 2 Docking sites 2 Dynamical fluctuations 2 Dynamics 2 Enzyme Activation 2 Enzymes 2 Isoforms 2 Key factors 2 MD simulation 2 Mitogen activated protein kinase 2 Mitogen-Activated Protein Kinase 12 2 Molecular Dynamics Simulation 2 Molecular dynamics 2 Molecular dynamics techniques 2 Movement 2 Multiple cellular functions 2 Phosphorylation 2 Plasticity 2