Calorimetry 2 Chagas disease 2 Crystallography, X-Ray 2 Drug Design 2 Enzyme Inhibitors 2 Geranyltranstransferase 2 IC 50 2 Magnesium 2 Models, Molecular 2 Phosphonic Acids 2 Protein Conformation 2 Thermodynamics 2 Trypanosoma cruzi 2 X ray crystallography 2 alkyl group 2 allyl compound 2 amine 2 antitrypanosomal agent 2 article 2 binding affinity 2 bisphosphonic acid derivative 2 chemical bond 2 complex formation 2 conformation 2 crystal structure 2 drug design 2 drug protein binding 2 drug synthesis 2 enthalpy 2 entropy 2