phosphatidylinositol 3 kinase 148 priority journal 130 controlled study 118 article 116 signal transduction 104 human 94 nonhuman 90 protein kinase B 86 Animals 76 human cell 76 Signal Transduction 74 protein expression 74 Humans 72 1-Phosphatidylinositol 3-Kinase 62 animal cell 62 protein phosphorylation 52 Proto-Oncogene Proteins c-akt 50 apoptosis 50 metabolism 50 enzyme activation 48 cell proliferation 46 female 46 mouse 46 unclassified drug 46 Apoptosis 44 Female 44 Phosphorylation 44 mitogen activated protein kinase 44 Mice 40 Cell Line, Tumor 36