Active site 4 Amino acids 4 Animals 4 Conceptual frameworks 4 Conformations 4 Energy profile 4 Histidine 4 Histidine residues 4 Humans 4 Hydrogen-Ion Concentration 4 Hydrophobic and Hydrophilic Interactions 4 Hydrophobic effect 4 Hydrophobic sites 4 Hydrophobicity 4 Ligands 4 Molecular dynamics 4 Molecular dynamics simulations 4 Myoglobin 4 Open conformation 4 Oxygen 4 Oxygen migration 4 Oxygen uptake 4 Protein Binding 4 Protein Structure, Secondary 4 Protonation 4 Protonation state 4 Rate enhancement 4 Side-chains 4 Significant differences 4 alanine 4