heme synthesis 60 article 54 nonhuman 48 controlled study 36 priority journal 36 animal experiment 32 male 32 5 aminolevulinate synthase 30 5-Aminolevulinate Synthetase 30 animal tissue 30 enzyme activity 30 mouse 30 Heme 28 Mice 28 Liver 24 Support, Non-U.S. Gov't 24 porphyrin 24 Male 22 porphobilinogen deaminase 22 Animals 20 animal model 20 Animal 18 heme 18 human 18 porphobilinogen synthase 18 Porphyrins 16 Ammonia-Lyases 14 Animalia 14 intraperitoneal drug administration 14 isoflurane 14