Allosteric Regulation 2 Allostery 2 Binding Sites 2 Conformational entropy 2 Crystallography, X-Ray 2 Entropy 2 Generalized Born surface analysis 2 Humans 2 Molecular dynamics 2 Protein Structure, Secondary 2 Serpin family 2 Thyroxine 2 Thyroxine-Binding Globulin 2 Thyroxine-binding globulin 2 allosterism 2 article 2 binding affinity 2 binding site 2 complex formation 2 conformational transition 2 controlled study 2 entropy 2 enzyme activity 2 hydrogen bond 2 molecular dynamics 2 priority journal 2 protein binding 2 protein conformation 2 protein interaction 2 protein localization 2