17 hydroxypregnenolone 4 enzyme activity 4 progesterone 4 17,20beta dihydroxypregn 4 en 3 one 2 3 beta-hydroxysteroid dehydrogenase type II 2 3beta hydroxy delta5 steroid dehydrogenase 2 Adrenal Hyperplasia, Congenital 2 Article 2 COS 7 cell line 2 DNA sequence 2 Female 2 HCG 2 HSD3B2 gene 2 Humans 2 Infant 2 Mutation, Missense 2 Progesterone Reductase 2 Puberty, Precocious 2 Spermiation 2 Steroids 2 Structure-Activity Relationship 2 Toad 2 Western blotting 2 amino acid substitution 2 aminoglutethimide 2 androstenedione 2 animal experiment 2 article 2 beta sheet 2 case report 2