controlled study protein function article 350 nonhuman 350 priority journal 332 Animals 262 protein expression 232 unclassified drug 210 animal cell 196 human 182 Humans 164 mouse 162 metabolism 148 human cell 132 Mice 130 animal experiment 130 protein analysis 108 animal tissue 104 genetics 100 animal 98 Article 96 male 94 Female 92 female 92 protein protein interaction 88 signal transduction 86 animal model 82 protein localization 82 enzyme activity 78 messenger RNA 76