priority journal article 148 nonhuman 136 controlled study 120 Animals 84 animal experiment 72 Heme 70 mouse 68 Mice 66 heme 66 male 60 Male 56 Humans 54 enzyme activity 54 animal model 50 animal tissue 50 human 48 5 aminolevulinate synthase 46 animal cell 44 heme oxygenase 1 42 metabolism 40 molecular dynamics 38 protein expression 38 rat 38 5-Aminolevulinate Synthetase 34 Heme Oxygenase-1 34 heme synthesis 34 human cell 32 unclassified drug 32 Porphyrins 30