porphobilinogen deaminase article 68 nonhuman 48 Hydroxymethylbilane Synthase 46 male 44 enzyme activity 36 Support, Non-U.S. Gov't 34 animal tissue 34 Liver 30 animal experiment 30 controlled study 30 mouse 26 priority journal 26 Animal 24 Male 24 Mice 22 liver 22 metabolism 22 Ammonia-Lyases 20 Animals 20 enzymology 20 heme synthesis 20 porphobilinogen synthase 20 rat 20 5 aminolevulinate synthase 18 Kinetics 18 animal model 18 heme 16 human 16 isoflurane 16