phenytoin anticonvulsive agent 8 article 8 controlled study 8 priority journal 8 Phenytoin 6 carbamazepine 6 female 6 Sodium channel 4 adult 4 aged 4 anticonvulsant activity 4 clinical article 4 drug mechanism 4 drug structure 4 electric shock 4 epilepsy 4 human 4 male 4 pharmacophore 4 quantum chemistry 4 topiramate 4 valproic acid 4 2 propylpentyl sulfamate 2 5 amino 1,3,4 thiadiazole 2 sulfonamide 2 5 tert butoxycarbonylamido 1,3,4 thiadiazole 2 sulfonamide 2 Adolescent 2 Adult 2 Aged 2 Anti-convulsant activity 2