oxygen affinity article 26 molecular dynamics 26 nonhuman 26 Oxygen 24 Models, Molecular 20 hemoglobin 20 Kinetics 18 Ligands 18 oxygen 18 Hemoglobins 16 computer simulation 16 priority journal 16 protein function 16 Animals 14 Binding Sites 14 Computer Simulation 14 controlled study 14 heme 14 Mutagenesis, Site-Directed 12 Mycobacterium tuberculosis 12 Truncated Hemoglobins 12 unclassified drug 12 Heme 10 Hemoglobin 10 Humans 10 Molecular dynamics 10 Thermodynamics 10 conformational transition 10 hydrogen bond 10