nonhuman unclassified drug priority journal 64 article 52 protein conformation 48 controlled study 42 Protein Conformation 40 Animals 32 molecular dynamics 30 Models, Molecular 24 Protein Binding 24 chemistry 24 metabolism 24 protein function 24 Humans 22 Article 20 Protein Structure, Secondary 20 binding affinity 18 circular dichroism 18 conformational transition 18 crystal structure 18 human 18 Molecular Dynamics Simulation 16 Rats 16 Recombinant Proteins 16 animal cell 16 protein domain 16 protein structure 16 Binding Sites 14 Molecular dynamics 14