drug structure 148 drug synthesis unclassified drug 114 article 106 nonhuman 70 controlled study 48 Animals 46 Humans 36 human 34 priority journal 34 Structure-Activity Relationship 30 structure activity relation 30 Trypanosoma cruzi 28 drug screening 28 Molecular Structure 24 drug activity 24 human cell 24 Cercopithecus aethiops 20 animal cell 20 in vitro study 20 proton nuclear magnetic resonance 20 synthesis 20 Article 18 Chagas disease 18 animal 18 chemical reaction 18 drug design 18 enzyme inhibition 18 Vero Cells 16 chemistry 16