drug solubility unclassified drug 16 article 14 controlled study 12 Article 10 drug synthesis 10 priority journal 10 drug structure 8 melting point 6 nonhuman 6 Animals 4 Molecular Structure 4 animal 4 binding affinity 4 chemical structure 4 drug formulation 4 drug isolation 4 drug stability 4 fluorescence 4 human 4 lipophilicity 4 photosensitizing agent 4 phthalocyanine derivative 4 physical chemistry 4 structure analysis 4 synthesis 4 viscosity 4 water 4 zeta potential 4 1,3 oxazole 2