disease course human 76 priority journal 76 Humans 70 article 68 nonhuman 66 controlled study 58 Animals 54 male 38 animal experiment 34 Male 32 Mice 32 animal model 32 animal tissue 32 female 32 mouse 32 protein expression 32 Female 30 Disease Progression 24 animal cell 22 Disease Models, Animal 20 disease association 20 human tissue 20 signal transduction 20 unclassified drug 20 disease severity 18 immunohistochemistry 18 adult 16 cell proliferation 16 pathology 16