controlled study priority journal 192 article 178 nonhuman 150 signal transduction 148 Animals 142 human 138 Humans 128 animal cell 120 human cell 118 mitogen activated protein kinase 114 mitogen activated protein kinase 1 114 protein expression 110 enzyme activation 106 metabolism 106 mouse 106 mitogen activated protein kinase 3 94 Mice 92 Signal Transduction 88 animal 76 unclassified drug 76 Phosphorylation 68 protein phosphorylation 68 Female 66 Article 64 cell proliferation 64 female 60 animal experiment 58 MAP Kinase Signaling System 56 phosphatidylinositol 3 kinase 56