controlled study male mouse nonhuman animal experiment 382 Animals 360 priority journal 354 Mice 344 article 334 Male 312 animal tissue 272 animal model 268 animal cell 224 female 162 animal 144 Article 142 protein expression 138 metabolism 118 unclassified drug 104 Female 102 human 98 Mice, Inbred C57BL 78 Humans 76 in vitro study 76 enzyme activity 72 in vivo study 72 drug effect 70 physiology 68 Mus 64 gene expression 62