controlled study male metabolism nonhuman 226 Animals 222 Male 222 animal 222 animal experiment 174 Article 172 priority journal 166 animal tissue 136 female 128 mouse 118 physiology 118 drug effects 102 animal cell 100 Female 92 Mice 92 article 90 adult 86 genetics 86 protein expression 80 human 78 Humans 74 animal model 66 unclassified drug 66 pathology 58 in vitro study 54 signal transduction 50 drug effect 48