article priority journal 218 controlled study 178 nonhuman 154 signal transduction 140 Animals 138 human 134 mitogen activated protein kinase 134 Humans 122 animal cell 114 human cell 110 mitogen activated protein kinase 1 108 enzyme activation 106 Signal Transduction 98 Mice 96 mouse 96 protein expression 96 metabolism 92 mitogen activated protein kinase 3 88 protein phosphorylation 72 Phosphorylation 70 unclassified drug 70 Female 64 Enzyme Activation 58 Western blotting 58 animal 54 female 54 Mitogen-Activated Protein Kinases 50 animal experiment 50 cell proliferation 50