antitrypanosomal activity controlled study 6 in vitro study 6 nonhuman 6 Antiparasitic activity 4 Article 4 Barton-Zard reaction 4 Bile acids 4 Cinchona alkaloid 4 Cinchona alkaloids 4 Hybrids 4 IC 50 4 IC50 4 Plasmodium falciparum 4 Trypanosoma brucei 4 Trypanosoma brucei brucei 4 antimalarial agent 4 antiparasitic agent 4 antiplasmodial activity 4 antiprotozoal activity 4 antitrypanosomal agent 4 artemisinin 4 article 4 bile acid 4 camptothecin 4 cytotoxicity 4 drug activity 4 drug cytotoxicity 4 drug synthesis 4 human 4