animal cell controlled study 62 nonhuman 60 phosphatidylinositol 3 kinase 56 priority journal 56 Animals 52 article 50 mouse 42 protein kinase B 40 Mice 38 signal transduction 38 Signal Transduction 34 protein expression 34 1-Phosphatidylinositol 3-Kinase 32 female 30 enzyme activation 28 Female 26 cell proliferation 26 Phosphorylation 24 Proto-Oncogene Proteins c-akt 22 apoptosis 22 Apoptosis 20 Humans 20 animal 20 cell survival 20 human 20 messenger RNA 20 metabolism 20 protein phosphorylation 20 animal experiment 16