8 ( 2,6 dimethylmorpholino)octylcarbamoyleseroline 2 Acetylcholinesterase 2 Alzheimer disease 2 Bace-1 2 Butyrylcholinesterase 2 Drug-target interactions 2 IC 50 2 Structure-based drug design X ray crystallography 2 acetylcholine 2 acetylcholinesterase 2 aminopyridine derivative 2 amyloid beta protein 2 ap 2238 2 article 2 beta secretase 2 beta secretase inhibitor 2 butyrylcholinesterase 1 2 catalysis 2 cholinesterase 2 cholinesterase inhibitor 2 complex formation 2 crystal structure 2 decamethonium 2 degenerative disease 2 disease course 2 donepezil 2 drug binding site 2 drug inhibition 2 drug potency 2