Puffs Calcium signals 8 algorithm 8 Algorithms 6 Calcium 6 Calcium Signaling 6 Inositol 1,4,5-Trisphosphate 6 Kinetics 6 article 6 calcium 6 calcium signaling 6 chemistry 6 inositol 1,4,5 trisphosphate 6 kinetics 6 metabolism 6 statistical model 6 Buffers 4 Cell Membrane 4 Computer Simulation 4 Cytosol 4 Dose-Response Relationship, Drug 4 Endoplasmic Reticulum 4 High resolution 4 Ion Channel Gating 4 Local signal 4 Mean field model 4 Models, Biological 4 Models, Statistical 4 Optical experiments 4 Physiological process 4