Porphobilinogen deaminase porphobilinogen deaminase 14 article 12 nonhuman 12 animal tissue 10 enzyme activity 10 male 10 animal experiment 6 controlled study 6 enzyme purification 6 porphobilinogen synthase 6 rat 6 Animals 4 Hydroxymethylbilane Synthase 4 Male 4 Rats 4 enzyme analysis 4 enzyme substrate complex 4 female 4 heme 4 heme synthesis 4 kidney 4 liver 4 metabolism 4 molecular weight 4 priority journal 4 protein expression 4 4 dimethylaminobenzaldehyde 2 5 aminolevulinate synthase 2 5,5' dithiobis(2 nitrobenzoic acid) 2