Down-Regulation priority journal 70 article 66 controlled study 66 nonhuman 58 down regulation 56 Animals 52 protein expression 46 human 42 Female 38 Humans 38 female 38 metabolism 32 human cell 30 mouse 30 signal transduction 28 Mice 26 animal cell 24 animal experiment 24 genetics 22 Rats 20 animal 20 animal tissue 20 rat 20 unclassified drug 20 Article 18 protein function 18 Apoptosis 16 Cell Line 16 Phosphorylation 16