DNA topoisomerase article 10 controlled study 8 nonhuman 8 enzyme activity 6 priority journal 6 Cells, Cultured 4 DNA 4 DNA Topoisomerases, Type I 4 DNA synthesis 4 DNA topoisomerase (ATP hydrolysing) 4 Kinetics 4 animal 4 camptothecin 4 cell culture 4 enzyme inhibition 4 kinetics 4 metabolism 4 rat 4 Alkenynes 2 Animal 2 Animals 2 Article 2 Asteraceae 2 Bucladesine 2 Camptothecin 2 Cell Differentiation 2 Cerebral cortex 2 Chromatin 2 Compositae 2