Article nonhuman controlled study 174 metabolism 142 genetics 134 gene expression 130 Animals 122 animal 122 priority journal 108 gene expression regulation 104 unclassified drug 90 mouse 88 animal experiment 82 animal tissue 80 protein expression 70 animal cell 60 male 58 Mice 56 human 54 female 52 messenger RNA 52 physiology 52 Humans 46 down regulation 42 Male 40 animal model 38 Female 36 Gene Expression Regulation 36 drug effects 36 upregulation 36