unclassified drug nonhuman 446 controlled study 370 article 366 priority journal 350 Animals 302 metabolism 266 genetics 260 human 230 Humans 228 animal 170 animal cell 164 Article 152 protein expression 152 gene expression 150 messenger RNA 136 mouse 120 human cell 116 Mice 114 nucleotide sequence 112 protein function 112 Molecular Sequence Data 104 chemistry 102 gene expression regulation 92 signal transduction 90 promoter region 86 RNA, Messenger 84 animal experiment 82 transcription factor 82 transcription regulation 82