priority journal nonhuman 458 controlled study 454 Animals 408 drug effect 366 animal 330 article 328 metabolism 310 animal cell 228 animal experiment 228 Article 214 mouse 212 drug effects 198 female 192 Mice 186 human 178 male 178 Female 168 animal tissue 166 Male 162 Humans 156 unclassified drug 154 physiology 152 protein expression 132 genetics 130 rat 124 animal model 116 Rats 108 in vitro study 98 signal transduction 94