article 123 nonhuman 108 heme 84 priority journal 83 controlled study 82 Heme 81 Animals 71 animal experiment 58 male 55 Male 52 enzyme activity 50 mouse 50 Porphyrins 49 Mice 48 metabolism 46 5 aminolevulinate synthase 43 animal tissue 42 5-Aminolevulinate Synthetase 40 Liver 39 animal model 39 rat 37 Humans 36 human 35 molecular dynamics 31 Rats 30 Support, Non-U.S. Gov't 30 Animal 29 oxidative stress 29 porphyrin 29 animal 28