unclassified drug nonhuman 415 controlled study 340 article 323 priority journal 322 Animals 281 metabolism 247 genetics 242 human 212 Humans 210 animal 158 animal cell 154 Article 152 gene expression 140 protein expression 139 messenger RNA 121 mouse 114 Mice 107 human cell 103 protein function 102 nucleotide sequence 98 Molecular Sequence Data 92 chemistry 92 gene expression regulation 86 signal transduction 82 animal experiment 76 promoter region 76 RNA, Messenger 73 transcription factor 73 transcription regulation 72