controlled study human priority journal unclassified drug Humans 215 article 193 human cell 188 nonhuman 174 Animals 135 animal cell 107 protein expression 91 metabolism 87 mouse 83 Article 74 Mice 71 female 69 in vitro study 64 animal 58 animal experiment 57 Cell Line 49 protein function 48 Female 46 chemistry 46 genetics 45 animal model 43 protein protein interaction 43 male 42 Cell Line, Tumor 40 cell proliferation 40 signal transduction 39