article enzyme activity nonhuman priority journal controlled study 339 Animals 250 animal experiment 159 animal tissue 157 unclassified drug 133 animal cell 122 mouse 112 protein expression 107 male 104 rat 104 Mice 92 animal model 81 Male 76 Rats 76 female 74 Female 73 signal transduction 72 Animalia 70 enzyme inhibition 70 Trypanosoma cruzi 63 Kinetics 56 Humans 49 metabolism 44 enzyme activation 42 protein phosphorylation 41 Enzyme Inhibitors 38