animal experiment metabolism nonhuman animal 363 controlled study 361 Animals 359 priority journal 239 Article 236 mouse 223 animal tissue 218 Mice 185 male 185 female 168 animal cell 163 animal model 163 Male 157 physiology 151 article 148 Female 140 unclassified drug 134 drug effects 118 protein expression 118 genetics 117 human 100 pathology 94 Humans 93 rat 82 enzyme activity 81 in vivo study 81 drug effect 76