Article metabolism nonhuman controlled study 476 Animals 422 animal 422 priority journal 320 animal experiment 236 unclassified drug 224 genetics 212 animal cell 210 mouse 204 animal tissue 196 drug effects 178 physiology 168 male 160 Mice 156 female 154 chemistry 142 protein expression 140 human 134 Male 130 Humans 124 Female 116 enzyme activity 114 animal model 96 signal transduction 92 gene expression 86 pathology 86 in vitro study 84