drug effect human metabolism Humans 101 article 69 controlled study 67 animal 57 Animals 55 human cell 53 priority journal 53 nonhuman 52 physiology 41 unclassified drug 37 female 30 Female 28 Mice 27 genetics 27 animal cell 26 rat 26 mouse 25 signal transduction 25 Rats 24 cell culture 23 Article 22 chemistry 22 protein expression 22 cell proliferation 21 dose response 21 animal experiment 20 Cells, Cultured 19