drug effects metabolism controlled study 251 Animals 231 animal 231 Article 224 nonhuman 215 priority journal 139 human 134 Humans 128 genetics 119 animal experiment 118 female 117 male 113 mouse 113 unclassified drug 98 Female 93 Mice 91 animal cell 91 animal tissue 89 Male 87 protein expression 87 physiology 79 chemistry 74 human cell 74 in vitro study 65 signal transduction 60 animal model 56 article 52 adult 50