controlled study metabolism priority journal nonhuman 472 Animals 383 animal 381 Article 332 article 250 genetics 243 animal cell 234 animal experiment 227 human 223 Humans 215 physiology 211 unclassified drug 208 mouse 207 female 200 protein expression 184 animal tissue 180 Mice 171 Female 165 male 163 Male 141 signal transduction 133 drug effect 131 drug effects 129 human cell 128 chemistry 123 animal model 110 in vitro study 106