controlled study male mouse nonhuman 454 animal experiment 365 Animals 340 priority journal 332 Mice 324 article 308 Male 293 animal tissue 260 animal model 256 animal cell 208 female 157 Article 142 animal 141 protein expression 130 metabolism 117 unclassified drug 100 Female 97 human 95 Mice, Inbred C57BL 76 in vitro study 73 Humans 71 enzyme activity 70 in vivo study 68 drug effect 67 physiology 66 Mus 61 human cell 60