controlled study human 182 human cell male Humans 130 article 130 priority journal 116 Male 115 nonhuman 89 female 84 protein expression 79 Female 68 animal experiment 64 adult 63 Animals 61 mouse 60 animal cell 57 in vitro study 54 Article 50 animal model 49 unclassified drug 44 Adult 43 Mice 40 cell proliferation 40 metabolism 40 Middle Aged 35 human tissue 35 clinical article 34 apoptosis 33 in vivo study 33