controlled study human male female 477 Humans 442 Male 439 article 437 adult 402 priority journal 378 Female 357 Adult 243 human cell 182 Middle Aged 176 nonhuman 170 Article 163 major clinical study 157 aged 153 clinical article 147 Animals 126 Aged 111 protein expression 103 animal experiment 102 mouse 95 animal cell 91 physiology 80 Adolescent 79 Argentina 79 animal 78 adolescent 77 metabolism 77