animal model controlled study male nonhuman 364 animal experiment 345 Animals 273 article 268 priority journal 258 mouse 256 Male 239 animal tissue 214 Mice 202 animal cell 146 female 122 protein expression 111 Article 92 rat 85 animal 83 unclassified drug 72 human 71 in vivo study 70 metabolism 66 Female 64 Rats 61 in vitro study 61 Humans 59 enzyme activity 57 drug effect 50 human cell 49 cell proliferation 45