animal model animal tissue male nonhuman 225 controlled study 214 animal experiment 211 Animals 169 mouse 165 article 161 priority journal 159 Male 143 Mice 133 animal cell 86 protein expression 75 female 66 Article 60 rat 54 enzyme activity 47 animal 45 in vivo study 42 human 39 unclassified drug 39 Rats 38 in vitro study 37 cell proliferation 35 messenger RNA 35 Female 33 drug effect 33 metabolism 32 immunohistochemistry 30