animal model male nonhuman 389 animal experiment 370 controlled study 364 Animals 290 article 287 priority journal 277 mouse 265 Male 260 animal tissue 225 Mice 207 animal cell 159 female 130 protein expression 113 rat 97 Article 94 animal 87 human 75 unclassified drug 74 Female 73 in vivo study 73 Rats 71 metabolism 66 in vitro study 64 enzyme activity 63 Humans 61 drug effect 50 human cell 49 cell proliferation 47