animal experiment animal model male mouse nonhuman 248 controlled study 239 Animals 187 Mice 185 article 172 priority journal 160 Male 159 animal tissue 153 animal cell 105 female 89 Article 76 protein expression 70 animal 67 in vivo study 59 human 57 metabolism 56 unclassified drug 56 in vitro study 52 Humans 48 Female 44 Mus 41 human cell 41 enzyme activity 37 drug effect 36 Mice, Inbred BALB C 35 Mice, Inbred C57BL 35