enzyme activity human 147 human cell controlled study 129 article 115 Humans 98 priority journal 87 protein expression 49 signal transduction 45 unclassified drug 43 cell proliferation 42 nonhuman 40 Animals 38 metabolism 38 Cell Line, Tumor 31 apoptosis 31 Article 30 mouse 30 Mice 27 animal cell 26 male 26 enzyme activation 25 Female 22 human tissue 22 Apoptosis 21 Cell Line 21 Western blotting 21 enzyme inhibition 21 Male 20 Cell Proliferation 19